Brightsurf delivers daily science news discoveries, articles, and the latest scientific breakthroughs. Your trusted source for science news today, covering nature news, science & technology, and scientific discoveries from leading research institutions worldwide.
A scoping review compared biosimilar regulatory guidelines across all WHO regions, identifying barriers to data transferability that may affect medication pricing, access, and reimbursement. The study aims to improve biosimilars' global accessibility.
A new study by Penn Medicine reveals significant gaps in online information about artificial intelligence (AI) and its impact on cancer research and treatment. The study found that only 33% of relevant webpages and 23% of videos were considered high-quality, with many omitting risks of AI use.
A study from UC San Francisco researchers reveals that regulatory differences around the world are slowing the development and adoption of biosimilars. The lack of standardization in biosimilar approval processes is a major obstacle for these cheaper alternatives to expensive biologics, which could lower costs for patients.
The study found that population-based pathogenic variant testing reveals different subsets of high-risk women than clinical risk factors and polygenic risk scores. This highlights the importance of incorporating PV testing into risk-based screening for breast cancer.
Institutional Special Needs Plan (I-SNP) enrollment was associated with significantly fewer hospitalizations for nursing home residents with dementia at the end of life, according to a retrospective cohort study. Effect sizes were larger for UnitedHealthcare (UHC) I-SNPs vs non-UHC plans. Plan maturity and volume likely impact success.
The study demonstrated a response to treatment in several tumor types, including lung cancer and head and neck cancers. A significant tumor shrinkage was observed in four out of 14 patients treated within the optimal dose range.
A phase 3 clinical trial found that apalutamide plus hormone therapy before and after surgery reduced the risk of metastasis or death by 20% compared to hormone therapy alone. Patients treated with this regimen had a higher pathologic response rate and experienced delayed subsequent therapy.
A phase 3 trial shows daraxonrasib, an oral RAS(ON) multi-selective inhibitor, improves overall and progression-free survival compared to chemotherapy in patients with metastatic pancreatic cancer. The treatment also demonstrated substantial tumor shrinkage or disappearance in patients with a known RAS G12 mutation.
Researchers discovered a novel Fe-N-C protective layer that enhances the stability of platinum-based fuel cell catalysts. The 'core-shell' design shields platinum from corrosion and creates a powerful electronic interaction at the interface.
A new machine-learning model uses pre-therapy PET/CT scans to estimate radiation dose to tumors and healthy organs, improving patient selection and reducing toxicity risk. The study's findings suggest a promising ability to predict post-therapy dosimetry, which may optimize treatment plans for individual patients.
A population-based screening trial evaluating a cell-free DNA multicancer early detection test found modest increases in diagnostic delay rates for head and neck, lung, and upper gastrointestinal cancers. These findings suggest that future trials may need to consider system-level spillover effects on healthcare resources.
A recent immigration ban could reduce the US physician and nurse workforce, exacerbating health care workforce shortages in already underserved communities. The study found nearly 24,000 physicians and 56,000 nurses from banned countries contributed to the US healthcare workforce in 2023.
The Society of Nuclear Medicine and Molecular Imaging recognized six new Fellows for their exceptional contributions to the field. The SNMMI Fellowship honors members who have demonstrated excellence in scientific discovery, educational efforts, or clinical practice.
This study found that Justicia carnea ethanol extracts effectively reduced oxidative stress markers, inflammation, and lipid peroxidation in a mouse model of chronic pancreatitis. The extracts also preserved islet glucagon expression, indicating potential therapeutic benefits for pancreatic damage.
This AAV platform integrates MGS4 peptide-guided capsid targeting, hypoxia-responsive elements, and dual shRNA vectors to selectively deliver chemokines and PNAi to NSCLC tumors. The combination of these elements aims to enhance antitumor immunity while suppressing tumor invasiveness.
A multicenter clinical trial found that implanting collagen tiles during brain surgery improved tumor control and lowered the risk of recurrence by 12.1% compared to current standard of care. Patients treated with tile-based radiation therapy (TBRT) had a median overall survival of 42.5 months, more than double the 17.6 months seen wit...
Vasken Dilsizian, MD, has received the Minoshima-Pappas Transformational Leadership Award for his vision and leadership in advancing nuclear medicine and molecular imaging. He has made significant contributions to the field of cardiovascular diseases through his innovative scientific work.
Scientists have identified dopamine as a key player in mediating stress-induced courtship suppression in male Drosophila fruit flies. The duration of stress exposure significantly influenced the persistence of suppressed courtship behavior, highlighting the importance of dopamine signaling in this process.
Cleveland Browns cornerback Denzel Ward is promoting Hands-Only CPR and empowering bystanders to save lives through a new American Heart Association campaign. The campaign aims to close the gap of bystanders performing CPR only about 41% of the time.
A recent study published in Cell has found that certain plants actively reduce their ability to take up iron when experiencing drought stress. This shift is driven by changes to plant roots that downregulate both immune systems and iron uptake machinery, allowing specific bacteria to thrive.
Couradeau will investigate how biocrust microbiomes adapt to thermal fluctuations, with implications for soil stability, fertility, and ecosystem services. Her research project includes novel components such as mesocosm experiments, global survey datasets, and citizen-science education.
A study by Brown University researchers found that exposure to violence is strongly associated with increased tobacco and e-cigarette use among adolescents. The study analyzed data from the Youth Risk Behavior Surveillance System and found that each form of violence exposure was linked to increased risk of using both substances.
Researchers from NYU Langone Health's Perlmutter Cancer Center presented new clinical findings on Merkel cell carcinoma, showing improved outcomes with pembrolizumab treatment. Additionally, a national study found that lung cancer screening has widened income-related gaps in survival rates, highlighting the need for equal access to care.
A new study published in JAMA found that using a cryoprobe for lung biopsies significantly increases the diagnostic yield compared to standard forceps, with nearly 10 percentage points higher accuracy. The 1.1-millimeter cryoprobe was shown to be safer and more effective than larger probes without crushing tissue samples.
Researchers at University of Illinois have developed a new process to stack silicon layers, enabling faster and more efficient chips. By sequentially building each layer on top of the previous one, they achieved high device performance across multiple tiers while meeting thermal constraints.
Researchers argue that biochar's long-term carbon storage potential and its soil improvement benefits should not be conflated. The authors call for a 'designer biochar' approach, tailoring products to specific end uses rather than marketing them as universally beneficial.
Researchers found that hydrochar improves soil structure while increasing soil organic carbon, with different feedstocks showing varying benefits. The study suggests hydrochar could become a customizable amendment for climate-smart soil management.
The NRG Oncology trial showed a sustained overall survival benefit for patients with advanced or recurrent endometrial cancer treated with pembrolizumab and chemotherapy, even after post-study immunotherapy. The benefit persisted in both mismatch repair proficient and deficient populations.
Researchers developed amine-functionalized biochar/cellulose acetate hybrid membranes using microalgae biomass, improving water filtration and reducing foulant adhesion. The modified membranes achieved a water flux of 169.1 L m⁻² h⁻¹ and 64.1% removal of natural organic matter.
Researchers at Columbia University have discovered a key mechanism in the formation of toxic tau filaments that contribute to Alzheimer's disease. The findings suggest that disrupting neuroproteasomes can trigger misfolding of tau into highly similar filaments, and that APOE variants may play a role in modulating this process.
The University of Tennessee at Knoxville is launching the Knoxville Quantum Accelerator, a collaborative effort to develop and commercialize quantum technologies. The initiative will support the development of an ecosystem that advances both fundamental discovery and applications.
A large international clinical trial led by UCL found that a gene test can safely spare many breast cancer patients of chemotherapy. The OPTIMA trial followed over 4,400 patients and suggested that those with hormone-sensitive breast cancer and low Prosigna scores can be treated safely with hormone therapy alone.
Researchers at Texas A&M University are designing how humans will build and survive on the moon, focusing on sustainable construction using lunar regolith. The institution's efforts aim to reduce costs associated with shipping materials to the moon, making it possible to produce rocket propellant locally.
Overusing adult skincare products during adolescence can lead to dry skin, irritation, and painful allergic reactions. Young skin is more sensitive and vulnerable to active ingredients than adult skin, making it essential to use gentle, moderate care with reliable preparations.
A new study finds herbal cigarettes can be as damaging as tobacco cigarettes, emitting comparable or even more harmful emissions. Fine particles and oxidative potential were measured, revealing a significant risk to cardiovascular and respiratory health.
A study found that women with Hashimoto's thyroiditis are more likely to have an evening chronotype and increased daytime sleepiness, associated with higher levels of thyroglobulin antibodies. The research highlights the importance of investigating underlying mechanisms for this association.
Researchers have developed a compact magnetoelectric antenna system, BlueME, to improve underwater robot communication. The technology enables robots to share information over long distances with minimal power consumption, overcoming challenges in oceanic environments.
The symposium aims to consolidate and expand partnerships in strategic areas such as energy transition, artificial intelligence, and health. The event will facilitate cooperation among researchers from São Paulo and the UK, with a focus on joint funding opportunities.
Researchers found that Ohio wall lizards' rapid population growth and adaptation to their new environment, with similar climate and habitat, contributed to their success. The study suggests that ecology plays a more significant role in the lizards' invasion than genetic factors initially thought.
Researchers developed an all-optical artificial synapse that uses light to mimic neural learning and perform in-sensor image processing. The device shows paired-pulse facilitation and depression, allowing it to both enhance and suppress signals, a requirement for realistic neural behavior.
Researchers at University of Würzburg discovered that inhibiting an enzyme involved in sugar metabolism makes cells more susceptible to cell death. The 'double agent' inhibitor blocks the enzyme while attacking another protective protein, leading to a paradoxical effect.
Scientists discovered a massive wildfire in the Rwenzori Mountains that shifted the region's ecology and altered plant life over 2,000 years ago. The study suggests that rising temperatures may be altering ecosystems once safeguarded by extreme alpine conditions.
Scientists discovered that oxygen levels in shallow oceans declined about 8 million years before the end-Triassic mass extinction, stressing marine ecosystems. The research provides a rough guide for the future as our oceans undergo acidification and deoxygenation.
Researchers at UT Institute of Agriculture identified a tick protein that could help block disease transmission before it fully happens. The study found that silencing the gene responsible for this protein reduced virus levels and hindered tick feeding.
A new study found that e-commerce warehouse jobs are more intense and dangerous than traditional warehouses, with workers facing pressure to move quickly and avoid breaks. The research suggests that Amazon's focus on fast delivery contributes to lower job quality, but alternative approaches are viable.
A team of researchers from Penn State and the University of Wisconsin-Milwaukee has been awarded a five-year, $3.2 million grant to study the biological mechanisms behind post-traumatic stress disorder (PTSD) and exaggerated fear responses. The research aims to better understand how traumatic events lead to long-lasting changes in the ...
Researchers at Penn State found that fungicide seed treatments have modest yield gains but often do not offset their costs. Financial benefits are likely only when treatment costs are low and soybean prices are high.
Researchers developed a sustainability index to assess tourism's impact on counties' well-being, finding mixed results with some positive economic and environmental gains but also concerns around housing affordability and violent crime. The tool provides insights for policymakers and destination managers to establish baselines, compare...
Tapendra Sodari, a UT Arlington physics Ph.D. student, has been awarded a $50,000 annually NASA fellowship to study the Equatorial Ionization Anomaly in Earth's upper atmosphere. His research aims to improve space weather prediction and protect critical technologies.
A new study by the University of Exeter reveals that Brazil and Mexico's EV growth has been shaped by factors beyond emissions and efficiency. The research highlights how domestic coalitions, market size, and foreign technology influences have driven policy decisions in both countries.
Researchers at the University of Toronto have developed a suite of low-cost, portable biotechnology tools to improve access to laboratory research and diagnostics in resource-limited settings. The decentralized biomanufacturing systems enable local production of high-value biological materials, reducing reliance on fragile internationa...
Insilico Medicine will present its end-to-end Pharma.AI platform and latest pipeline, highlighting the synergy between AI-driven drug design, quantum algorithms, and automation labs. The company has built an extensive therapeutic portfolio across various areas and rapidly advancing its internal R&D pipeline.
A study using a mouse model demonstrates that microplastics can exacerbate respiratory tract inflammation and alter immune responses associated with allergies. The researchers found that the particles remained detectable in the lungs for at least 14 days, leading to an increased migration of lymphocytes and eosinophils.
Severe obstructive sleep apnea is associated with higher lung cancer incidence and mortality, driven by mechanisms such as HIF activation, immune remodeling, and enhanced cancer stem cell properties. Long-term adherent CPAP therapy shows promise in mitigating these risks.
A study by University of Exeter experts found that unified and local efforts can support a thriving environment and improve community well-being. The researchers propose tech-driven, community-led action to rescue local environmental enforcement from funding cuts and jurisdictional confusion.
A new study identifies CLPTM1L as a regulator of membrane raft formation and EGFR-dependent proliferative signaling in glioblastoma. High CLPTM1L expression was associated with shorter patient survival, while depletion impaired GBM cell viability and proliferation.
Professor Marc Koper has been recognized for his pioneering research in electrochemistry and catalysis, crucial for developing sustainable energy technologies. His team's theoretical models explain copper's pivotal role as a catalyst in converting CO2 into hydrocarbons.
Researchers develop a highly adhesive hydrogel that reinforces the interaction between functional layers and electrodes, improving electrical output performance and mechanical stability. The resulting device exhibits ultra-long-term stable operation, anti-drying, anti-freezing, and anti-swelling properties.
Frontiers won two EPIC Awards for its landmark whitepaper on responsible AI use in research and publishing, and a digital campaign highlighting research integrity. The awards recognize the institution's commitment to making science open and trusted.
Research suggests a symbiotic relationship between fish and their gut microbes produces minerals influencing ocean chemistry and the marine carbon cycle. The study found vibrio bacteria play a key role in ichthyocarbonate formation, which is linked to global nutrient cycles.