Brightsurf delivers daily science news discoveries, articles, and the latest scientific breakthroughs. Your trusted source for science news today, covering nature news, science & technology, and scientific discoveries from leading research institutions worldwide.
Researchers developed mRNA-encoded nanobodies to combat colorectal cancer, offering new hope for patients resistant to conventional immunotherapies. The treatment demonstrated superior efficacy against sporadic and colitis-associated colorectal cancer.
Scientists have developed an adaptable materials platform that can safely deliver a wide range of genetic medicines, including vaccines, cancer treatments, and gene-silencing drugs. The new platform uses modular building blocks that self-assemble to form nanoscale delivery particles with reversible 'host-guest' linking system.
Researchers at Memorial Sloan Kettering Cancer Center investigate ferroptosis as a potential target for cancer treatment. They also develop an AI model to analyze country-specific factors driving global cancer outcomes. Additionally, the institution introduces an AI-based incident analysis approach to improve patient safety.
The Long Life Family Study, a long-running international investigation, has revealed insights into features of healthy aging. Researchers have found that most long-lived families have better cardiovascular health, including healthier blood pressures and lower rates of diabetes.
Researchers developed open-source software to measure AI model energy use, revealing trends in how design affects power requirements. The tool can automate the search for efficient parameters, helping lower energy costs and environmental impact.
Researchers found that Palaeolithic sign sequences are statistically comparable to the earliest proto-cuneiform script, dating back 40,000 years. The analysis of over 3,000 geometric signs on 260 objects revealed complex and informative systems used by early humans to convey information.
A new collaborative clinician education program will equip cardiologists and OB-GYNs with practical tools to identify and treat cardiovascular risk in midlife women. The program aims to close treatment gaps and provide proactive, integrated care during menopause.
The Morrow Plots, established in 1876, have been a hub for long-term agricultural research and outreach. The plots have directly impacted farming practices by proving methods like crop rotation and judicious fertilizer use boost crop yield and soil health.
Researchers used mathematical modeling to find that even people with minimal concern for others would choose to self-isolate when sick, suppressing diseases in the long-term. The study suggests that only a small amount of altruism is needed to achieve indefinite suppression as an alternative to herd immunity.
Researchers have achieved a crucial building block for new quantum computers by realizing a novel type of quantum logic gate that works with pairs of photons in four different states, enabling new opportunities for optical quantum computing. This milestone opens up possibilities for faster calculations and improved stability.
The inaugural article in Microbiology Outlooks connects within-host genomics and evolutionary theory, reframing virulence as a context-dependent strategy. The research has implications for vaccine design, antimicrobial stewardship, and epidemic control strategies.
Physicists at the University of Utah have developed a new, streamlined system for generating orbital angular momentum in electrons, allowing for cheaper and more abundant materials. The innovation uses natural symmetry and vibrations of atoms to control electron momentum.
Scientists detected statistically significant changes in global atmospheric temperatures in response to three major natural events: Mount Pinatubo, Australian wildfires, and Hunga Tonga eruption. The study's findings suggest that these events may not have played a role in the acceleration of global surface warming in recent years.
Researchers have shown that ocean temperature patterns limit the global spread of droughts, with synchronised droughts affecting only 1.8% to 6.5% of global land. The study identified 'drought hubs' in regions like Australia, South America, and southern Africa.
Researchers have discovered that two osteoporosis drugs, etidronate and tiludronate, can bind to excess iron, reducing oxidative stress and preventing cell damage. This finding holds promise for patients with iron overload diseases, but further studies are needed to confirm its potential as a treatment.
Gupta received the award for her article on systematic gaps in reporting variants of uncertain significance (VUS) and their reclassifications. Her study found that at least 1.6% of variant classifications used in electronic health records were outdated based on current ClinVar classifications.
A new study published in Building and Environment shows that larger indoor greening systems can make spaces feel up to two degrees cooler and more comfortable. The analysis also highlights the importance of using the right systems, lighting, and maintenance to unlock the full potential of indoor greening.
Researchers found that youths born in the 1990s spent more time playing formal sports compared to their peers, with those from higher social class backgrounds dominating these opportunities. This shift away from informal play raises concerns about the costs and benefits of commercialized youth sports.
New research demonstrates a micro–light-emitting diode (microLED) design that improves both efficiency and beam directionality. The redesigned microLEDs deliver substantially higher efficiency, converting more power into usable light compared to conventional designs.
A large registry study in Finland found that 70% of antipsychotic medication use among older adults was off-label. Risperidone and quetiapine were the most commonly used medications off-label. The study highlights the need for alternative treatments and clearer guidelines for monitoring metabolic side effects.
Researchers found a strong inverse correlation between Arctic sea ice extent and Indian summer monsoon rainfall on interannual timescales. Decreased Arctic sea ice variability during June to July leads to increased rainfall over western and northwestern India, indicating a westward shift in the monsoon season.
The study reveals a novel hydrogen-bonding motif in the deprotonated dimer of phosphoric acid, which may be key to understanding proton transport in phosphoric acid-based systems. This finding provides insight into the molecular origin of phosphoric acid's extraordinary proton conductivity.
Researchers found that farming practices, unsafe sanitation, and domestic animals linked to infection risk. Household-level interventions are essential for accelerating elimination, especially when community-wide strategies fail near elimination.
A Mayo Clinic study found that the brain enters a deep sleep state after a seizure, mimicking memory storage and strengthening disease. This phenomenon, called seizure-related consolidation, could help explain why epilepsy worsens over time and why memory and mood problems are common in people with the condition.
Researchers at Rice University have developed a new method to grow patterned diamond surfaces that can decrease operating temperatures in electronics. This approach uses microwave plasma chemical vapor deposition to create ordered layers of diamond crystals on substrates, allowing for controlled seed placement and scalable growth.
A systematic review found that post-disaster mental health problems may peak 9-18 years after the event, with depression being the most common issue. The study suggests that long-term recovery approaches are needed to alleviate mental health burdens, particularly for at-risk communities.
A team of researchers has developed a novel method to track the Earth's greenness by calculating its centre of mass. They found that the 'green centre' oscillates between northernmost positions in mid-July and southernmost positions off the coast of Liberia in March, with a consistent northward shift across all seasons.
A study on Japanese plum reveals the genetic architecture underlying key phenological stages, including flowering onset, full bloom, and fruit development period. The research identified stable genetic loci and candidate genes that can be used to accelerate breeding for climate-resilient plum varieties.
Researchers explore piezoelectric electrospun fibers that generate crucial electrical signals for tissue engineering and biomedical applications. These "smart" scaffolds have high flexibility, biomimetic structure, and tunable morphology, offering potential for enhanced tissue repair.
The development of spatial transcriptomics has advanced gene expression understanding, but selecting suitable analytical approaches is challenging. A database curated SpatialToolDB addresses this by classifying over 600 ST analytical tools and providing access to processed datasets.
A grave in northern Serbia contains the remains of over 77 individuals, mostly women and children, who suffered violent deaths including bludgeoning and stabbing. Genetic analysis revealed that most victims were not related, suggesting a deliberate targeting of these groups.
Researchers found that radiation-resistant cancer cells are vulnerable to NK cell-mediated killing due to increased expression of specific cellular membrane proteins, creating an 'evolutionary double-bind'. The combination of radiation therapy and NK cell-based immunotherapy was more effective in suppressing both sensitive and resistan...
A new rice gene, GSN7, has been discovered that can simultaneously increase grain yield and improve quality. The study found that precise manipulation of this gene can overcome the long-standing trade-off between yield and quality in rice breeding.
Researchers developed an AI method to predict mastoidectomy shape before surgery, enabling better navigation and visualization for surgeons. The approach achieved a high Dice score of 0.72 compared to popular medical imaging models.
Researchers developed a multilayered insulated superhydrophobic (MISH) coating that maintains repellency up to 90°C, outperforming conventional coatings. The coating's insulating layer reduces heat transfer, preventing condensation and maintaining 'never-wet' properties.
Research shows that expert birders have more compact attention- and perception-related brain areas, linked to accurate bird identification. These structural changes persist in older birders and may benefit cognition as people age.
A new study found that Black young adults experiencing high levels of online racism are more likely to use digital mental health tools. The research also showed that these individuals were more likely to engage in online mental health communication, regardless of their anxiety or depression symptoms.
Researchers at King's College London have developed highly reactive aluminium molecules that can break apart tough chemical bonds. The team discovered a new compound called cyclotrialumane, which exhibits unprecedented reactivity and retains its structure in various solutions.
Researchers found that implanted cuff electrodes can trigger unintended nerve stimulation during MRI, causing discomfort or pain. The study recommends more refined guidelines and careful safety considerations to mitigate this risk.
Scientists at the University of Chicago have created Prussian blue analogs that can achieve 99.9% lithium purification, opening up new opportunities for separating industrial waste ions from environmental streams. The unique structure of Prussian blue analogs allows for selective filtering and purification.
A new study found that almost all people with obesity (BMI ≥ 30 kg/m²) exhibit increased body fat mass and health-related complications. Clinical obesity is associated with a 3-8 times higher risk of cardiovascular disease and type 2 diabetes compared to non-obese individuals.
Researchers review schizophrenia mechanisms, including neurotransmitter dysregulation and immune dysfunction, to develop next-generation therapies. Promising treatments include TAAR1 agonists, muscarinic modulators, NMDA receptor enhancers, and probiotics targeting the gut-brain axis.
A study by St. Jude Children's Research Hospital found that radiation therapy contributes to hearing loss in children treated for brain tumors, leading to greater cognitive decline. Children with severe hearing loss experienced a more significant decline in cognitive measures compared to those without.
Researchers at IISc have mapped a neural circuit that links stress to itch. Stress activates specific neurons in the lateral hypothalamic area, which directly regulate itch and reduce scratching behavior. This study provides new insights into the complex relationship between emotional states and sensory perception.
Tumor-infiltrating lymphocytes (TIL) therapy is a form of immunotherapy that harnesses the body's natural defenses to fight cancer. Researchers at Ochsner MD Anderson have successfully treated advanced melanoma using this innovative approach, with many patients experiencing tumor shrinkage or elimination after treatment.
A new study analyzing global Google Trends data reveals a sharp increase in online searches for crisis hotlines, particularly in recent years. The findings suggest that digital help-seeking signals can provide timely insight into population distress and demand for crisis resources.
A new study published in Acta Psychiatrica Scandinavica found that people with mental illness who use AI chatbots risk experiencing a worsening of their condition, particularly in terms of delusions and mania. Researchers are calling for increased awareness among healthcare professionals about the potential risks of AI chatbot use.
The Norwegian University of Life Sciences has launched ClimateDataForBuildings, an open platform providing energy and climate modelling data for over 3,600 European locations. The platform delivers high-resolution CERRA reanalysis data for building performance and HVAC design.
Researchers at the University of Waterloo have discovered a way to convert microplastic waste into acetic acid, the main ingredient of vinegar, using sunlight. The breakthrough offers a promising new approach to reducing plastic pollution through photocatalysis, creating a valuable chemical product.
A new study by SMART has identified a strong statistical association between global air connectivity and patterns of multinational corporations' investments. The research found that few layovers meant more subsidiaries, with cities having better flight connections to influential hubs outperforming those with less-connected destinations.
Researchers found that silencing bacteria can worsen heart infections by promoting aggressive biofilm growth and reducing antibiotic effectiveness. The study highlights the need for targeted therapeutic strategies against infectious endocarditis.
Researchers developed an AI approach to visualize subtle tissue changes in the pancreas for type 2 diabetes. The study created an extensive data set and trained deep learning models that accurately predicted diabetes status and identified potential biomarkers.
Astronomers have found that the fundamental physical processes generating auroras are common to different celestial bodies, including the largest moon in the solar system. Observations of Ganymede's auroras reveal locally fragmented patches similar to those on Earth and Jupiter, suggesting a universal mechanism for aurora formation.
Researchers developed a technology that precisely controls the internal structure of semiconductors using heat, enabling faster AI computations with reduced electricity. The approach improves the performance of next-generation artificial intelligence hardware.
Researchers at the University of Oulu have developed new bio-based resins that match or exceed the performance of fossil-based counterparts. The resins are produced from biomass-derived platform chemicals and offer a critical sustainability advantage: chemical recyclability.
NUS food scientists develop a healthier, tastier kombu by co-fermenting enzyme-treated kombu with lactic acid bacteria and aroma-producing yeast. The resulting probiotic blend promotes nutrient bioaccessibility and introduces fruity aromas.
Researchers at the University of Basel have unlocked the magnetic properties of individual bacteria, enabling them to navigate using an Earth-based compass. This discovery holds promise for medical applications, such as magnetically controllable microrobots, and environmental research.
Research at University of Eastern Finland found that positively charged polystyrene nanoparticles increase early embryo mortality in European whitefish under stressed conditions. The study suggests that surface charge plays a critical role in toxicity assessment, with negatively charged particles experiencing reduced harmful effects.
Researchers from the University of Ottawa have developed a groundbreaking biomaterial that combines strength, adaptability, and biological compatibility for soft tissue repair. The hydrogel is made from synthetic peptides and can be precisely tailored through chemical design, making it an attractive alternative to existing biomaterials.
Researchers at the Max Planck Institute for Brain Research discovered that stressed animal cells, including neurons, assemble inactive ribosomes into tightly linked pairs, known as disomes. This novel mechanism relies on a specific piece of ribosomal RNA called an expansion segment to form a precise RNA-RNA interaction.