Brightsurf delivers daily science news discoveries, articles, and the latest scientific breakthroughs. Your trusted source for science news today, covering nature news, science & technology, and scientific discoveries from leading research institutions worldwide.
A study from the University of California, Davis, and Argentina's National Research Council found that 71% of southern giant petrel chicks sampled had plastic in their bodies. Even small amounts of plastic ingestion were associated with changes in nutrition, metabolism, and immune response in young chicks.
Researchers have developed a novel AlphaFold-based method that introduces a repulsive force between predicted structures, allowing for the sampling of multiple conformational states. This enables the prediction of diverse protein conformations rapidly and accurately, with potential applications in drug design and protein engineering.
A KAIST team uses AI to identify optimal material recipe for 3D-printable, highly stretchable material. The material printed reliably on a DLP 3D printer and showed high stretchability, extending to over six times its original length.
A clinical trial funded by NIH found that PAXLOVID does not improve Long COVID symptoms, but its extended duration did not cause serious side effects. The study recruited 959 patients and monitored symptoms over six months.
Researchers propose a new theory explaining why humans perceive colors as combinations of red, yellow, green, and blue. They suggest that our brain simplifies the natural world's color palette to encode the range of colors, capturing the idea of opponency in color vision.
Dr. Castro's research found that companies affected by ASC 606 reported higher revenue growth and more useful earnings information for investors. However, increased discretion also created opportunities for strategic manipulation of financial results when facing analyst pressure.
Researchers discovered coordinated chemical changes across multiple sites in bumble bee queens as they aged and took on reproductive roles. These changes suggest that chemical signals may be influenced by shared biological processes rather than operating independently.
Researchers found that adolescent binge alcohol exposure caused lasting changes in brain function, disrupting communication between astrocytes and synapses, and persisting into adulthood. Improving astrocyte function partially recovered these effects, suggesting a potential new approach for addressing persistent behavioral effects.
NEW HORIZON PRESS LIMITED participated in ACS Fall 2026, connecting with researchers and scholars to introduce its academic journals and publishing initiatives. The meeting highlighted advances in chemistry, materials science, and environmental science, with a focus on sustainability and interdisciplinary research.
Researchers have found that nano-biochar can rapidly transform silver ions into silver nanoparticles under alkaline conditions, with superoxide radicals playing a key role in the process. The study also showed that the structure of nano-biochar and pH conditions can control metal transformations in water.
A new review suggests that artificial intelligence could help scientists develop more precise and mechanism-guided biochar management strategies for acidic soils. Researchers should distinguish between organic and inorganic sources of alkalinity in biochar to improve predictive models.
Research by Prof. Samsun Knight reveals that streaming services' algorithms prioritize familiar content, leading to overexposure and decreased engagement. To combat this, Prof. Knight suggests exploring less familiar content and incorporating human recommendations to discover new artistic movements.
Researchers at the University of Washington have created two new spinels made of silver, chromium, and selenium ions, which exhibit magnetic properties up to 400 Kelvin. The spinels transform when exposed to air, with the original losing magnetism at a lower temperature compared to the second spinel.
Researchers found that aerobic exercise significantly improves executive functions, including planning, task-switching, and focus, in post-menopausal women. Regular exercise can help preserve cognitive health and reduce the risk of Alzheimer's disease, with benefits observed as early as three months into the program.
A prospective cohort study found that higher parental vitamin B12 and maternal RBC folate levels before and after conception, respectively, were associated with lower birth defect risk. This suggests that the nutritional status of both parents during the periconceptional period may play a role in preventing birth defects.
A team of researchers at TU Delft has developed a tactile drone that uses soft tactile sensors in a human-like hand to detect and grasp branches before landing. The drone's approach is robust and accurate, even in situations where vision alone is unreliable.
Motion-triggered cameras revealed the frequency of 'nectar robbing' in Hawaiian flowers, which damages flowers and reduces nectar availability. In contrast, plants were able to produce fruit and viable seeds despite damage, indicating adaptations to the stress.
A new analysis by Yale University economists reveals that correcting just one assumption in the cost-benefit analysis leads to a net cost of rolling back vehicle emissions standards. The study shows that attributing a zero value for avoided air pollution and incorrectly valuing fuel efficiency trade-offs result in a $790 billion net be...
The combined herbaria will create an unmatched archive for studying plant diversity in the southeastern US, with over 1.7 million specimens. The consolidation will preserve a scientific legacy and advance understanding of plant life, supporting human well-being for generations to come.
Researchers used computational modeling to simulate how electrons interact with manganese ions, predicting emission lines that could be useful for analyzing rapidly expanding objects like supernova remnants. The findings suggest that these emission lines could provide insight into the chemical evolution of galaxies, stars, and the univ...
A new University of Oklahoma study examines whether targeted social media messages can increase parents' knowledge and help them take action to prevent teen vaping. The research aims to give parents the information and tools they need to recognize vaping and help prevent its use with their children.
A comparative survey of nearly 150 career civil servants found that Brazilian civil servants were more likely to mobilize against democratic breakdown through collective acts, while US civil servants adopted individualized and cautious strategies. Strong professional cultures and networks emerged as key facilitators for pushback among ...
Researchers found that corisin, a bacterial protein fragment, drives tissue fibrosis by disrupting the cell's quality-control system. Antibody treatment can help by blocking corisin, demonstrating its biologically active and causally supported role in disease.
Researchers found that AI-generated ads can be ineffective when the technology is not matched to the advertisement's theme and intent. Marketers should use AI to enhance campaign ideas, not as a shortcut. The study suggests a stronger match between AI and ad themes can increase consumer engagement.
A team of researchers discovered specific microbes in Antarctica's soils are endemic, meaning they are found only on the continent and nowhere else on Earth. The study found that these microbes are uniquely adapted to the harsh environment, growing more slowly but being highly resilient.
Prostate cancer affects 1 in 8 men, with 60% diagnosed in men 65 and older. Clinical trials like Alliance's help improve early detection and treatment, reducing mortality rates by half since 1993. These trials also explore new treatments and survivorship strategies.
The updated guideline provides recommendations for preventive medications for both chronic and episodic migraine, taking into account new research and medication options. Clinicians are advised to assess the impact of migraine on quality of life when choosing a preventive medication, and to discuss the strength of evidence, possible si...
C.S. Mott Children's Hospital is the first hospital in the US to implant an expandable heart valve, the Autus Valve, during the FDA review phase. The device is designed to grow with children and can potentially reduce the need for replacement surgeries.
Binghamton University professor Stephanie Tulk Jesso is developing cognitive behavioral architecture to enable robots to understand human needs and improve healthcare outcomes. Her research focuses on co-designing AI systems with nurses to reduce errors and enhance patient care.
The Europlanet Science Congress 2026 will cover various topics in planetary research, including the Solar System, exoplanets, and artificial intelligence. The conference will feature over 125 scientific sessions and keynote talks, with around 1200 planetary scientists attending from 40 countries.
The $8 million grant will unite Boise State, University of Idaho, and three community colleges to develop resilient microelectronics for extreme environments. The project aims to create long-term research infrastructure and train students in materials science and engineering.
A nationwide study found that air conditioning usage cut annual heat-related deaths by half in the US, saving over 5,000 lives. Moderate AC usage provides the most benefits, while over-usage may flatten benefits.
A new study reveals that the loss of kelp forests has a significant impact on microbial levels, leading to changes in ecosystem functioning and potentially affecting human services such as nutrient retention and carbon storage. The research highlights the importance of considering the microbial component in understanding ecosystem change.
Researchers developed a method to distinguish authentic ancient clay artifacts from fakes by analyzing the magnetic properties of the clay. By measuring the temperature needed to erase magnetism acquired over time, the method can determine the age and authenticity of the artifact.
Researchers created a 3D platform using human-derived nerve cells and Schwann cells to study nerve cell formation and myelin coating development. The platform enables functional myelin formation and allows for the study of nerve damage and repair, as well as the testing of potential treatments.
A study by Goethe University and Universitätsmedizin Frankfurt has found that seminal fluid can facilitate infection of skin cells with the monkeypox virus. The researchers discovered that protein fragments in seminal fluid form fibers that promote attachment of the virus to human cells, increasing the risk of transmission through sexu...
Scientists have found that short peptides can remain stable and fold into shapes that may give them biological functions in highly acidic conditions similar to Venus's cloud layer. This discovery opens up new possibilities for the search for life on planets that don't resemble Earth.
Researchers developed flexible Te/PET films for ultrafast all-optical terahertz modulators, achieving high modulation depth and ultrasensitive response. The device maintained stable performance under bending deformation, enabling reliable information processing for intelligent sensing and neuromorphic optoelectronic systems.
Researchers have developed a wide-field hyperspectral camera that captures real-time spectral changes from hundreds of nanoparticles simultaneously, revealing hidden heterogeneity in electrodeposition. The technique, called wide-field Fourier transform hyperspectral imaging, solves the throughput bottleneck in conventional dark-field s...
Researchers identify HLA-E as a key regulator of metastasis-initiating hepatocyte states, linked to IFN-γ–JAK–STAT3 pathway. Chronic immune pressure contributes to metastasis initiation in HCC, suggesting a new target for limiting immune-driven metastasis.
Overfermentation of cocoa beans can cause smoky, leathery, and cheesy off-flavors, with elevated concentrations of short-chain carboxylic acids and phenols detected. A simple measurement using test strips can help detect the onset of overfermentation, preventing the development of off-flavors.
Researchers investigated NDUFA11's role in Parkinson's disease, finding it maintains mitochondrial function and integrity. Impaired NDUFA11 function contributes to mitochondrial dysfunction, oxidative stress, and PD-related abnormalities.
Researchers discovered a new kind of planar defect, called 'filling fault,' in half-Heusler compounds. This defect arises from the local filling of vacant sublattices and introduces stoichiometric deviations, affecting material properties.
Researchers discovered plant bundles from the Wuwangdun Tomb, containing rice, millets, and other cereals, wrapped in oak leaves, with similar structures to modern zongzi. The bundles were likely used as funerary offerings, distinguishing them from their modern counterparts.
Research discovered calcium-binding protein CSE in multicellular cyanobacteria, regulating cell-to-cell communication and forming tissue-like structures. This finding suggests that functional principles of higher organisms existed in simple bacteria a billion years ago.
A clinical trial has demonstrated a new treatment that reduces bleeding within the heart muscle and preserves heart function in severe heart attack patients. The trial tested a peri-reperfusion therapy that limits hemorrhagic myocardial injury after primary percutaneous coronary intervention.
High-risk patients taking evolocumab had a 20% lower risk of death compared to those on placebo, according to a Mass General Brigham study. The study found that intensive LDL-C lowering with evolocumab was associated with lower risk of heart attack and stroke, as well as improved survival in high-risk patients without a prior CV event.
Tumor-infiltrating lymphocyte therapy has shown potential in several types of solid tumors, including metastatic melanoma, breast cancer, and ovarian cancer. Despite challenges, the approach has favorable clinical outcomes, and researchers are exploring combination strategies and advanced technologies to improve treatment durability.
Transient intestinal inflammation can leave irreversible changes in the gut lining, leading to Crohn's disease and ulcerative colitis. Long-term inflammation rewires intestinal stem cells, preventing normal regeneration and creating chronic disease.
The Lancet Haematology series examines how clinicians can better identify and track treatment effects on patients during and after blood cancer treatment. Digital tools, such as symptom-reporting apps and artificial intelligence, could support changes in care, but must be accurate and equitable.
Researchers at MSK have identified a protein called integrin alpha-5 as a key driver of lung metastasis across several cancer types. A new three-drug combination that includes epcoritamab, rituximab, and lenalidomide is effective in almost all patients newly diagnosed with follicular lymphoma, offering a potential alternative to chemot...
The Atrax sounding rocket test has provided significant reentry vibration data that will help improve modeling and simulation tools for the W93 warhead. This data will enable scientists and engineers to design nonnuclear components more precisely, reducing risk and improving the overall survivability of the system.
Scientists have identified a microbiome signaling system that controls intestinal movement, revealing a potential new direction for treating constipation-predominant irritable bowel syndrome. The discovery points to restoring combinations of microbial signals to restore normal function.
Higher TMAO concentrations were associated with older age, cardiometabolic risk factors, and brain atrophy, but not cognitive performance. The study suggests TMAO may be a marker of systemic aging processes rather than a direct mediator of neurodegeneration.
Researchers investigate how consumers incorporate dollar stores into their household food purchases and explore health concerns surrounding the proliferation of dollar stores. The study aims to develop educational resources and tools to help consumers stretch their food budget and maintain a nutritious diet utilizing dollar stores.
A new AI method called neural posterior estimation (NPE) uses genetic sequences to analyze the evolution of infectious diseases. This allows for real-time management of epidemics and epizootics, with the ability to add new data at any time.
Researchers aim to identify biological differences among patients to guide treatment with precision therapeutics and computational approaches. The goal is to improve treatment outcomes for schizophrenia, a condition that affects perception of reality.
Researchers have discovered an epigenetic mechanism that allows a rare tree species to track its age and trigger flowering. The study found that a decline in DNA methylation levels directly activates reproductive genes, enabling the tree to transition from vegetative growth to flowering.
The Workshop on Public Health Policy, Risk Perception, and Infectious Disease successfully bridged the gap between epidemiological modeling and policy implementation for infectious diseases. Participants discussed practical challenges and mutual benefits of using models to support public health decision-making.
A new study examining 39,761 students in Ontario school boards found that 1 in 5 students used AI for emotional needs, with those who did being more likely to struggle with serious emotional problems and feel isolated. The study urges parents, educators, and clinicians to pay attention to why young people turn to chatbots.
A new kinetic model reconciles field observations and laboratory experiments, showing that temperature dependence and multiphase kinetics resolve observed growth rates. The model considers reactivity, diffusivity, and concentration gradients of chemical species across gas and condensed phases.
Dr. Emily Flanagan's five-year NIH grant will investigate how energy intake and expenditure influence infant growth and future obesity risk. The study aims to improve energy-intake standards for infants and identify critical periods for interventions promoting healthy growth.
Researchers found lead levels were 7 times higher near airports compared to other areas of Portland, with aviation fuel as the dominant source. The study highlights the need for soil testing to address lead exposure risks for children.
A recent study from the Dog Aging Project found that dogs with five or more chronic diseases were more than twice as likely to die as dogs living with only one diagnosed condition. Chronic diseases can dramatically shorten a dog's lifespan, highlighting the importance of managing multiple diseases together rather than individually.
The American Academy of Neurology has launched BrainHealth.com, a public resource providing expert-reviewed information, tools, and stories to improve brain health. The website offers trustworthy guidance, practical resources, and personal stories to help people navigate brain health with confidence.
A new study from the University of California San Diego reveals that the brain tracks subtle variations in breathing to decode neural activity patterns. Researchers found a precise connection between breathing patterns and brain activity, offering new avenues for understanding disorders like SUDEP and SIDS.
Research reveals individual breaths at rest create unique brain wave patterns, affecting mental processes such as thinking, attention, and emotional regulation. The study suggests that brain-body interactions are crucial for assessing and treating neuropsychiatric patient populations.
Researchers developed tools to compare tumor microenvironments and predict treatment response by analyzing spatial transcriptomic data. The new tools provide a detailed map of tumor cell organization, enabling clinicians to quickly analyze and compare tumor 'floor plans' and determine the best course of treatment.
Researchers propose framework for closed-loop haptic interaction in VR/AR, linking tactile sensing, intelligent processing, and physical feedback. The review identifies flexible electronic skins and four research priorities to close the haptic interaction gap.
Researchers developed a compact built-in prompt gamma-ray neutron activation analysis (PGNAA) system to measure uranium loading and ionic contaminants in hydrometallurgy processes. The system provides on-site trends to support decisions on resin switching and elution timing.
Researchers have discovered a mechanism that could help develop disease-resistant plant varieties with high yield potential. Steroid hormones regulate a molecular switch controlling the immune response, allowing plants to prioritize growth over defense against pathogens.
A study by Aalto University reveals pro-Russian hackers are using 'gamified' DDoS attacks to undermine public trust in governments and institutions, with cryptocurrency-based rewards for successful attacks. The researchers urge companies and governments to counteract the effects of propaganda and psychological intimidation.
A team of researchers has discovered four sets of dual 'Little Red Dots' (LRDs) in the early universe, indicating a possible link between galaxy mergers and rapidly growing black holes. The findings suggest that black hole mergers could be responsible for the rapid growth of black holes in the early universe.
A recent study found that TYW5 gene dysregulation is associated with circadian disruption and schizophrenia, affecting locomotor rhythms and prefrontal synaptic ultrastructure. Altering TYW5 expression levels in mice led to changes in behavior, including increased locomotor activity and anxiety-like behavior.
PTHrP inhibits BMP2-induced osteochondral differentiation by inactivating the PI3K–AKT signaling pathway, preserving cartilage phenotype and promoting chondrogenesis. This finding suggests PTHrP's potential application in BMP2-based cartilage tissue engineering.
Researchers propose that wave function phase is the source of randomness in quantum mechanics, potentially leading to new AI advancements. This idea contradicts current understanding and warrants experimental verification.
A recent study published in Cell Death & Differentiation highlights the role of endoplasmic reticulum stress proteins in osteoarthritis, revealing their contribution to inflammation and tissue remodeling. The research identifies a promising protein, PDIA4, which may serve as a therapeutic target for limiting disease progression.
The EU-funded projects SpongeBoost, SpongeScapes, and SpongeWorks have published a joint policy brief recommending aligning EU policies to scale up sponge restoration across Europe. The policy brief highlights the importance of restoring the natural sponge function of landscapes to strengthen water and climate resilience.
Research reveals that the visual systems of mice and monkeys follow the same efficient coding principle, but process different sensory inputs. This principle explains why mice have stronger responses to movement due to their coarse patch-based vision.
Pharmaceutical contamination in soil and air has severe ecological impacts, affecting animal, plant, and microbial communities. The review highlights the need for interdisciplinary research to understand the dynamics of pharmaceuticals in soil and their long-term implications for ecosystem health.
The journal aims to pioneer a holistic understanding of disease as a dynamic ecosystem, integrating study of micro-environment, microbiota, metabolite, nervous system, and pathophysiology. Pathology Research covers a broad spectrum of pathology-related disciplines, including surgical and molecular pathology, artificial intelligence in ...
Researchers have found that Astragalus polysaccharide protects against ischemic stroke by modulating the gut-brain axis, a two-way communication network between gut microbes and the brain. The compound also reduces inflammation and preserves neurons, suggesting a new route for treating the world's leading cause of long-term disability.
Researchers at Kumamoto University have created a mobile drug delivery platform using polyrotaxanes to simplify targeting the liver. The platform achieves cellular uptake efficiency comparable to conventional systems, while reducing manufacturing complexity.
Researchers at PolyU have engineered a novel tunnelling field-effect transistor using 2D nanomaterials, breaking through the 60 mV decade’ boundary to create ultra-low-power, high-performance ICs essential for emerging AI chips. The breakthrough paves the way for energy-efficient computing and next-generation AI chips.
Cobalt-based electrocatalysts have shown high efficiency in reducing nitrate to ammonia, with some achieving 100% Faradaic efficiency. Researchers have discovered alloying cobalt with other metals and engineering crystal structures can fine-tune the reaction pathway to favor ammonia production.
Researchers discovered a natural compound, hederagenin, that slows kidney aging in diabetes by reversing epigenetic silencing of the anti-aging gene Klotho. Hederagenin reduces Klotho promoter methylation, restoring Klotho protein levels and curbing cellular senescence.
Research reveals that snake embryos coil in a right-handed spiral due to the detachment of the slow-growing gut, which tethers the lengthening body. This coiling force directs the embryo to grow to the opposite side of the yolk, resulting in half of near-hatching embryos being right-handed and the other half left-handed.
A study published in Advanced Materials Interfaces reveals that proteins with exposed arginine residues selectively accumulate on protein-resistant coatings, compromising biocompatibility of medical devices. Researchers developed a new design guideline for predicting and controlling protein corona formation at the molecular level.
Specific plastid ion channels enable rapid calcium signal transmission to chloroplasts, strengthening plant defense response to recurring stress. Calcium waves relay information about attacks, triggering jasmonic acid synthesis and defense gene expression.
Despite declining confidence in CDC, FDA, and NIH, Americans' confidence in their own healthcare providers remains high. A recent survey found that 87% of respondents trust their doctor or nurse to provide trustworthy information about public health, while confidence in these agencies has declined to 59-64%.
A Southwest Research Institute study of Solar Orbiter data provides the most detailed view of the heliospheric current sheet, revealing a clear change in ion composition tied to magnetic polarity flips. The findings offer new insights into the origin and composition of the solar wind.
Scientists at MUSC Hollings Cancer Center discovered a protein called lysyl oxidase that helps triple-negative breast cancer cells survive. Blocking LOX creates a weakness, which can be exploited with a second drug to block tumor growth without chemotherapy.
A new species of spider, Hexura vandal, has been discovered in Idaho's Rocky Mountains, expanding the known range of the genus by 500 kilometers. The species is a predator that attacks and is considered likely endangered due to habitat pressure from logging and wildfires.
Researchers found that a Western-style diet exacerbated male infertility in mice with genetic mutations, leading to lower fertility and poorer sperm quality. The study suggests that lifestyle factors contribute to the severity of infertility in men with underlying genetic susceptibility, providing new insights into personalized fertili...
A cross-sectional study suggests that seeking emotional support from generative AI is a unique marker of psychological distress in children and adolescents. Clinical frameworks and digital literacy programs should distinguish between functional AI assistance and algorithmic interfaces as a digital refuge for emotional needs.
A crossover randomized clinical trial found that cannabis edibles impaired simulated driving performance at blood THC concentrations below per se thresholds. The study's findings suggest that even low doses of THC can have significant effects on driving ability.
Researchers analyzed 8.1 million emergency department visits to identify the most at-risk patients during heat waves, offering a near-real-time opportunity to implement protective measures. The study suggests that delays in identifying those most at-risk are no longer necessary, and timely evidence is increasingly essential for effecti...
Six UK universities have renewed their unlimited OA publishing agreement with JMIR Publications, allowing corresponding authors to publish APC-free in all JMIR journals. This sustainable model establishes a more predictable and equitable publishing environment.
Left atrial appendage closure during open-heart surgery is recommended for high-risk patients undergoing cardiac surgery to reduce stroke risk. The LAACS-2 trial found closure provided a 56% reduction in stroke risk for those at high risk, but no significant benefit for those at lower risk.
Researchers developed a computational model to study aging in 40 types of human tissue, identifying three major aging patterns and underlying molecular changes. Tissues show bimodal structural aging, with accelerated aging from 35-40 and 55-60, coinciding with fertility decline and menopause.
A new AI framework, AdvWT, uses realistic fading, cracks, and corrosion to test vulnerabilities in AI vision systems. It achieves near-perfect attack success rates on lightweight CNNs and transformer-based models, and can also be used to restore naturally damaged traffic signs.
Researchers at UC San Diego will develop optimized red blood cells to temporarily boost human performance and health through enhanced oxygen delivery. The project has the potential to improve athletic performance and treat conditions involving oxygen delivery to tissues.
A large randomized trial and meta-analysis found that immediate coronary angiography does not improve 30-day survival in patients with out-of-hospital cardiac arrest without ECG ST-elevation. The findings support current guideline recommendations against routine immediate coronary angiography in these patients.
A new study found that community first responders did not improve short-term survival after cardiac arrest, but did increase bystander CPR and defibrillation rates. The study's findings suggest that the effect of first responders on survival is highly dependent on the time available for intervention.
A new study has shown that catheter-directed thrombolysis significantly reduces primary clinical outcomes in patients with pulmonary embolism, including a lower rate of cardiorespiratory decompensation or collapse. The treatment improved short-term clinical outcomes compared to standard anticoagulation therapy alone.
FAU will investigate how undergraduate STEM education can better connect scientific discovery with workforce preparation, leveraging industry partnerships and research infrastructure. The project aims to strengthen students' technical and professional skills, scientific problem-solving, and career confidence.
Researchers found that Americans tend to support religious exemption requests from those who share their political views, but are skeptical of requests from those who hold opposing views. This study highlights the potential for ideological biases to influence perceptions of religious freedom protections.
Researchers at Binghamton University found that memory shifts as we age, with declines in accuracy from the 20- to 30-year-old age group to people in their 50s. Hippocampal processes start to decline by midlife, making middle age a transition point for memory formation.
Two imaging techniques, optical coherence tomography (OCT) and intravascular ultrasound (IVUS), were compared in patients with true distal left main bifurcation lesions. OCT was found to be noninferior to IVUS in guiding stenting, suggesting it may be an alternative option.
The CorCal Outcomes trial found no difference in major cardiovascular events when statin initiation was based on coronary artery calcium compared to traditional risk factor assessment. Patients recommended statins based on CAC scores were more adherent with their medication.
The EVAOLD trial suggests that routine invasive treatment is more effective than a selective approach in older patients with NSTEMI, a common type of heart attack. The trial found that the selective approach did not demonstrate noninferiority to routine invasive treatment for major cardiovascular events.
Researchers found thylacines used high-impact snapping to catch small prey, contradicting myths of ferocious predators. The unique skull shape allowed them to withstand powerful bite forces, setting them apart from other carnivorous mammals.
Human-driven fires have reshaped the Amazonian forest over the last 10,000 years, with a significant impact on vegetation and species composition. The research reveals that fires were almost exclusively human-driven, with a dramatic decline in fire frequency over the last 700 years.
A mathematical model developed by researchers from Hasanuddin University suggests that combining vaccination, treatment, quarantine, and educational campaigns could curb Mpox transmission. The model showed that a full-control strategy produced the greatest reduction in infections, with a 97.85% decrease in the total number of infected ...
Researchers discovered a long-lived monocyte-derived population in the lung that provides essential support for durable T cell immunity. The study suggests that enhancing interactions between innate immune cells and memory T cells could be one such strategy.
Researchers have developed a biomarker score called BioTAK to identify broken-heart syndrome, which affects postmenopausal women and is triggered by emotional or physical stress. The score uses blood biomarkers to distinguish the condition from a heart attack, providing new insights into disease mechanisms.
Immunotherapy for gynecological tumors offers durable responses and survival benefits, but complex immune evasion mechanisms and tumor microenvironment pose challenges. Current treatment options, such as ICIs and adoptive cell therapy, show promise, but precision immunotherapy is needed to improve patient outcomes.
Researchers discovered a temperature-locking phenomenon in a bulk organic conductor, where Joule heating raises the sample temperature, giving rise to a resistive-switched state. The material exhibits an inverse Ohm's law, showing an unusual behavior where voltage and current are inversely proportional.
A new calculator predicts the impact of different treatment combinations on blood pressure, kidney function, and serum potassium levels. The calculator provides personalized estimates based on patient characteristics, which can help clinicians overcome uncertainty and prescribe effective therapies.
A 14-day wearable ECG monitor improved the diagnosis and treatment of arrhythmias in patients with unexplained syncope. Monitoring more than doubled the detection of clinically significant cardiac arrhythmias and led to earlier diagnosis, resulting in a 50% reduction in all-cause mortality.
A large randomised trial found that targeted lead placement in cardiac resynchronisation therapy did not improve outcomes in patients with heart failure. The study compared targeted and standard lead placement and found no difference in death or first heart failure hospitalization rates.
Researchers in South Africa's Karoo region are redefining the relationship between Indigenous knowledge and modern science, as they study the ethnoastronomical knowledge of local communities. The project, which involves elders and knowledge holders, highlights the dynamic and adaptive nature of traditional knowledge, which continues to...
Researchers from Tohoku University and Queen Mary University of London have developed a low-temperature method for graphene production, utilizing acetylene gas and cerium oxide. This breakthrough enables precise control over the material's final form and paves the way for sustainable resource recycling.
Researchers developed an ultrafast infrared near-field optical microscopy technique that enables frequency-selective imaging of phonon polariton without sacrificing ultrafast time resolution. The technique reveals ultrafast optical modulation of phonon polariton in van der Waals heterostructures.
Researchers at Pohang University of Science and Technology have developed a speaker system that can deliver sound to a single listener, using dual-domain metamaterials and a compact ultrasonic transducer. The system achieves highly directional audio generation, focusing sound at the front and blocking parasitic noise at the back.
Researchers from HKUST develop 'one-pot' testing platform TEMPO for rapid, single-step nucleic acid testing, reaching attomolar sensitivity comparable to laboratory methods. The platform has potential applications in infectious disease surveillance and genetic screening.
The CIP2A protein regulates DNA repair during cell division and influences tumor response to radiotherapy. It controls Polθ activity and maintains its recruitment to damaged DNA sites through interaction with PP2A.
A new porous material has been developed to detect and adsorb copper ions, with a detection limit of 40.76 nM and a high adsorption capacity of 1902 mg/g. The material shows specific fluorescent recognition and cooperative adsorption capabilities, enabling efficient heavy metal monitoring and pollution treatment.
A survey of 365 Australian adolescents aged 10-15 found that those who began using social media at a younger age reported more symptoms of anxiety and depression. The study suggests that delaying children's first exposure to social media may be a promising policy for protecting mental health.
A new study reveals that China's retired electric vehicle batteries could unlock six billion tons of climate gains by 2050 if spatial mismatches are resolved. By prioritizing high-value utilization pathways like power storage and direct recycling, cost savings and emissions reductions can be delivered. The study suggests that establish...
Researchers have discovered a method to create complex polymer patterns using low-power lasers, enabling the production of water-repellent coatings and optical devices. The technique also has potential applications in data storage, electronics, and biomedical devices.
A clinical trial found that AZD5462, a new oral medication, was well-tolerated and improved cardiac remodeling and blood flow in patients with heart failure. The results suggest that AZD5462 may be a promising treatment option for patients with chronic heart failure.
Researchers have identified a new resistance gene, PsFwC9, that protects peas against Fusarium wilt, a devastating disease causing yield losses up to 30%. The gene, located on chromosome 4, confers resistance through a distinct mechanism, opening up new possibilities for understanding plant defense and stacking resistance genes.
KAIST researchers analyzed key challenges in microbial food industry and proposed growth strategies for next-generation protein market. The study emphasizes the importance of manufacturing readiness, market entry strategies, and regulatory compliance in commercializing microbial foods.
A new study found that 72% of Australian women wear a different size under US sizing and 65% under EU sizing. The researchers suggest that some women may be compensating for shoes that don't accommodate their foot width. The study highlights the need for more inclusive footwear sizing systems and clearer sizing information.
A one-year tailored exercise program significantly reduced atrial fibrillation (AF) burden and improved cardiorespiratory fitness in patients with non-permanent AF. Despite lack of significant improvements in quality of life, the exercise intervention showed meaningful benefits in measures of fitness and hospitalisations.
Plozasiran administered by subcutaneous injection every three months has shown substantial reductions in triglyceride levels, with a 78-80% decrease observed after one year. The treatment also demonstrated a significant reduction in acute pancreatitis events, with a 78% decrease in trial populations.
A recent study found that catheter ablation does not significantly improve quality of life related to atrial fibrillation, but reduces AF recurrence. The PVI-SHAM-AF trial showed that both catheter ablation and a sham procedure improved AF-related quality of life, with no significant difference between them.
Researchers found that gene silencer therapy may be beneficial for patients with transthyretin amyloid cardiomyopathy, with attenuated benefits observed when combined with TTR stabilizer therapy. The study will be presented at the European Society of Cardiology Congress in Munich, Germany.
A community-based trial in rural China found that intensive blood-pressure lowering intervention reduced dementia risk by 15% compared to usual care. The intervention also showed benefits in cognitive impairment and serious adverse events. This scalable approach may help reduce the increasing burden of dementia globally.
A large international study found that routine referrals to cardiologists or internists improved cholesterol levels in prostate cancer patients, but did not lead to fewer heart attacks, strokes, or cardiovascular deaths. Researchers noted that fewer participants experienced these complications than expected, making it harder to determi...
A new study finds that a TAVI-first strategy is noninferior to a PCI-first strategy in patients with severe aortic stenosis and concomitant coronary artery disease. The trial showed that fewer patients in the TAVI-first group ultimately underwent PCI, and life-threatening bleeding occurred at a lower rate with the TAVI-first strategy.
Transcatheter tricuspid valve repair improved heart failure hospitalization and all-cause mortality in patients with severe tricuspid regurgitation. The TRIC-I-HF trial demonstrated a significant benefit in reducing hard clinical outcomes, including quality-of-life improvements and sustained reductions in mortality.
The ACASA-TAVI trial found that non-vitamin K antagonist oral anticoagulants (NOACs) significantly reduced imaging signs of leaflet thrombosis by 45% compared to antiplatelet therapy after TAVI. NOAC monotherapy also demonstrated a comparable safety profile, with lower risk of severe bleeding events.
The TIME-HF trial found that a nurse-led intervention improving guideline-directed medical therapy uptake and clinical outcomes in patients with heart failure in India led to increased days alive and out of hospital and a 22% reduction in deaths at 2 years. This collaborative care model may serve as a blueprint for other settings with ...
A phase IIb trial found that AZD5462, an oral relaxin agonist, improved cardiac function in patients with heart failure, particularly at the lowest dose, with no safety concerns noted. The study suggests that AZD5462 may be a promising addition to existing therapies for heart failure.
A nationwide study found that early initiation of statins after type 2 diabetes diagnosis was associated with a 15% lower relative risk of dementia over 10 years. Statin treatment was also linked to a 10% lower risk of dementia in patients who initiated treatment between one and five years after diagnosis.
The H-HeFT trial found no significant difference in death or heart failure events with hydralazine–isosorbide dinitrate versus placebo in patients with heart failure and reduced ejection fraction. High treatment discontinuation rates emphasize the need for careful evaluation of hydralazine–isosorbide dinitrate's tolerability profile.
A large randomized trial and meta-analysis found no evidence that metformin reduces cardiovascular outcomes in patients with heart failure with reduced ejection fraction and diabetes. Metformin remains beneficial for glucose lowering but lacks cardioprotective benefits.
Researchers at KAIST have developed a low-cost smartphone-based technology to detect hidden cameras by analyzing reflections from objects. The technology, called SweepLED, uses deep learning-based analysis to distinguish camera lenses from ordinary objects, achieving 94% detection accuracy. The technology has potential to be developed ...
A virtual e-health system (VIRTUES) has been found to be as safe and effective as standard care for monitoring cardiac implantable electronic devices, with significant cost savings and patient satisfaction. The system uses transmission reports from the patient's device to provide real-time monitoring and communication with the physician.
The AIR-STEMI trial found that functional coronary angiography significantly reduced major cardiovascular events and complications by 38% and 37%, respectively, compared to conventional angiography. The study showed that this approach can improve current care for high-risk patient populations by selecting and treating only clinically i...
A digital strategy identified untreated patients with heart failure and invited them for specialist evaluation, resulting in a more than doubling of guideline-recommended SGLT2 inhibitor therapy. The approach showed promise in increasing timely access to effective treatments for this major public health issue.
A randomized trial found that digital outreach improved short-term statin refill rates among patients with cardiovascular disease or high cardiovascular risk who had fallen behind on their prescriptions. Adaptive, sequential health system outreach strategies support improved cardiovascular prevention in population health programs.
A new study confirms the safety of rapid heart attack testing but finds no reduction in emergency department stay length. The 0/1-hour pathway was compared to the standard 0/3-hour pathway and was found to be noninferior in terms of safety.
Remote exercise-based cardiac rehabilitation shows promise as an additional option for patients, but does not replace centre-based rehabilitation. The study found that remotely delivered exercise improved physical capacity and was used by a substantial proportion of patients, despite not increasing overall participation.
The REACT study reveals that 57.1% of participants aged 18 to 70 had atherosclerotic plaques, despite no symptoms or previous diagnosis. Most people with coronary atherosclerosis also had the disease in other arteries, making portable ultrasound devices a promising screening tool.
A new study found that atorvastatin reduces major cardiovascular events by 30% in people aged 70 and older without known cardiovascular disease, diabetes, or dementia. However, it did not improve disability-free survival. The results inform treatment guidelines for older adults, who are underrepresented in previous trials.
The AMUNDSEN trial found that evolocumab significantly improved LDL-cholesterol goal achievement after a heart attack, but did not show early cardiovascular benefits. Patients who received evolocumab had a higher rate of LDL-C goal attainment compared to standard care.
A phase 2 clinical trial found that a monoclonal antibody targeting interleukin-6 achieved sustained reductions in inflammation biomarkers for six months in patients with chronic kidney disease. The therapy, known as pacibekitug, was well-tolerated and showed favorable effects on additional biomarkers associated with cardiovascular risk.
Starting evolocumab before or during percutaneous coronary intervention for acute myocardial infarction significantly reduces LDL cholesterol levels. However, this strategy does not improve short-term clinical outcomes, including death and cardiovascular hospitalization, during the first year. The study suggests that lowering LDL chole...
Pacibekitug, a long-acting monoclonal antibody targeting interleukin-6, produced sustained reductions in inflammatory markers in patients with chronic kidney disease. The treatment also showed dose-dependent effects on other inflammatory markers, such as fibrinogen and lipoprotein(a).
Atrial fibrillation patients with prior intracranial haemorrhage face uncertain stroke prevention strategies. Edoxaban trial findings indicate a need for individualised decision-making, highlighting increased bleeding risk in this population.
A study found that silent atherosclerosis is prevalent in 57.1% of adults, increasing with age and affecting men earlier than women. Conventional risk assessment often misses this disease, highlighting the need for early imaging detection and potential precision medicine approaches.
Atrial fibrillation patients who have had a heart attack may be at increased risk of bleeding if given potent antiplatelet therapy combined with direct oral anticoagulants. The EPIDAURUS trial found no significant benefits regarding cardiovascular events, suggesting these treatments may not be necessary for this patient population.
The PREMIUM trial suggests that dual antiplatelet therapy with a potent P2Y12 receptor inhibitor plus aspirin is recommended for up to 12 months after a STEMI. However, further studies are needed to determine the optimum antiplatelet regimen in patients after a STEMI.
The A-CLOSE trial found that extended dual antiplatelet therapy (DAPT) provides greater protection against cardiovascular events, but clopidogrel monotherapy reduces bleeding risk. Long-term antiplatelet strategies should be tailored to each patient's clinical characteristics.
The LIBREXIA ACS trial found that patients remain at risk of recurrent cardiovascular events after an acute coronary syndrome. No difference was observed in cardiovascular events or bleeding with milvexian compared to placebo, despite expected anticoagulant activity.
The SWITCH SWEDEHEART trial found prasugrel comparable to ticagrelor for major cardiovascular events, but with lower major bleeding risk. Prasugrel reduced major bleeding by 4.2% compared to ticagrelor.
A team from Tokyo Metropolitan University developed a system to test magnetohydrodynamic aerobraking for spacecraft reentry. They successfully generated strong magnetic fields using an electromagnet, exceeding previous results with permanent magnets.
A team of researchers led by Texas A&M University has discovered Atlantic herring possess exceptionally high diversity in their MHC class II genes, a group of immune genes involved in recognizing pathogens. This diversity is shaped by natural selection driven by the evolutionary
Researchers have developed an ultracompact gene activation tool called TIGRa, which can target multiple genes simultaneously and is smaller than CRISPR-based tools. TIGRa was tested in a mouse model and showed promising results in treating retinal degenerative conditions, including glaucoma.
Researchers at Yale University have discovered two ancient, extinct giant tortoise lineages using a new combination of computational tools. The findings can aid conservation efforts in the Galapagos archipelago by unlocking the genetic diversity of extinct species.
Researchers developed new guidelines to study molecular biomarkers associated with stroke recovery. The recommendations aim to identify biological signals that can help clinicians determine the most effective therapies for each patient at the right moment. The guidelines also emphasize the importance of creating national biomarker cent...
Researchers discovered how tumors interact with the body to grow and spread, revealing a new target for cancer therapy. Metadherin, a protein encoded by the MTDH gene, mediates this metabolic-immune crosstalk, supporting tumor growth and metastasis.
Researchers at Texas A&M University are working on a project to develop a mobile and efficient drilling system that combines faster drilling technology, real-time rock analysis, and artificial intelligence to identify valuable minerals in real time. This project aims to reduce the time needed to evaluate potential deposits of rare eart...
The researcher will investigate how infected cells live and die, and what chemical signals they release to surrounding cells. This work could lead to better antiviral drugs and virus-based cancer treatments.
A new Concordia study suggests that reducing fast fashion's environmental impact can be achieved through changes in manufacturing, transportation, and consumer use. By producing fewer garments, designing them with longevity in mind, and cutting back on air freight, the fashion industry can achieve significant environmental benefits.
Researchers developed SOT-MRAM, a fast and energy-efficient memory tech, to address AI's increasing energy needs. The technology can reduce energy consumption by up to 5x, making it suitable for edge devices and applications where power is limited.
A new study identifies a distinct population of lung vein cells that contribute to scar tissue formation, a process known as fibrosis, in diseases like pulmonary fibrosis. The researchers found that targeting a specific signaling pathway can prevent lung scarring and inflammation.
A new study found that nearly 20% of eligible adults in Medicaid expansion states are at risk of losing health coverage due to insufficient or inconsistent work hours. Women, unmarried people, and those with limited education are disproportionately affected.
Two new research chairs at UVic will focus on improving climate-ready ocean stewardship and prevention-focused health research. Elliott Hazen will lead efforts to identify early ecosystem warning signals and collaborate with Indigenous communities to support climate-responsive ocean stewardship. David Almeida will establish a digital a...
A new study from the University of Georgia found that Joro spiders eat different insects and a wider variety than native orb weavers, suggesting they don't compete for food. However, Joros are still taking up physical space, but can often be found alongside native spiders in their webs.
Cyclin D1, a protein linked to cancer, paradoxically promotes chronic inflammation in non-proliferating senescent cells, which can lead to age-related disease. Research suggests that targeting cyclin D1 may be a promising strategy to reduce inflammation and promote healthier aging.
A new theranostic pair, 68Ga/177Lu-NYM096, shows excellent tumor uptake in clear cell renal cell carcinoma lesions and demonstrates early evidence of tumor response in patients. The radiotracer can identify tumors and deliver targeted radiotherapy, mitigating toxicity issues common with treatment.
A warming tropical pool has temporarily slowed Antarctic ice loss by triggering a Rossby wave train and reorganizing moisture transport, resulting in a 695 billion-ton mass gain. This phenomenon, linked to tropical warm-pool warming, demonstrates the complex interactions between atmospheric circulation and ice sheet mass changes.
The American Academy of Neurology launches BrainHealth.com, a public resource providing expert-reviewed information, tools, and stories for brain health. The website offers evidence-based guidance and practical resources for individuals to make informed choices for their brain health at every stage of life.
Thomson Reuters developed a frontier AI model named Thomson that rivals big foundation models with a $40 million development cost. The approach allows organisations to build and deploy frontier AI systems without major frontier labs' resources, addressing governments' and companies' need for sovereign AI systems.
Researchers found that impaired peroxisomal function can increase insulin secretion while promoting insulin oxidation and disrupting pancreatic beta cell maturity. Healthy peroxisomes play a role in protecting insulin from oxidative modification and degradation, and helping beta cells maintain their specialized characteristics.
Researchers are studying the male role in early pregnancy loss, focusing on paternal epigenetics and its impact on fertility and pregnancy. By analyzing sperm from bulls with high and low fertility, the team aims to understand how nongenetic changes to DNA affect embryo development and gene regulation.
Researchers have created a high-resolution functional map of human immune cells, revealing intricate circuits that govern health and disease. The dataset provides a powerful framework for designing cancer immunotherapies and treating autoimmune conditions, and serves as a foundation for AI models of biology.
Researchers developed fluorescent molecules that allow imaging of DNA inside living cells at unprecedented resolution, and in preserved cells, close to the width of the double helix. The team tested the probes on cancer patients and found DNA to be noticeably looser and more spread out in tumours.
Researchers have mapped how the immune response in people with sepsis changes over time, revealing three distinct immune states. This finding could lead to targeted treatments for sepsis patients, as the immune state doesn't match the clinical stage of sepsis.
Digital tools are transforming clinical research, public health readiness, healthcare institutions, and consumer choices. Citizen science initiatives using mobile apps are also growing, with three types of citizen science identified: with-the-people, by-the-people, and for-the-people.
Researchers have identified a subset of B cells known as atypical memory cells as the primary precursors of autoantibody-producing cells during SARS-CoV-2 infection. These cells adopt a markedly different biological program, leading to increased autoantibody production. The study provides new insight into how viral infections can trigg...
A study found that higher breastfeeding intensity is associated with more favorable early postpartum lipid profiles among women with prior gestational diabetes. Greater breastfeeding intensity may be linked to a more favorable early cardiometabolic profile in these women.
A team led by Professor Paulin Straughan is studying how urban design and infrastructure influence physical activity, mobility, and social participation among older adults. The goal is to create a sustainable approach to wellbeing-management through
A new generation of intelligent decision support methods and software tools will be developed to enhance supply chain resilience, optimize healthcare operations, and strengthen emergency response coordination. The HOPE project aims to create a lasting area of excellence in human-centered AI, serving as a trusted partner for government,...
A recent study aims to evaluate the effectiveness of Healthier SG in cancer screening, focusing on improving systems and boosting habits. The research seeks to address knowledge gaps in evidence-based planning for Singapore's preventive care agenda.
Researchers found that reef fish exposed to motorboat noise as embryos and juveniles grow smaller and have impaired survival skills. The study suggests that limiting motorboat traffic near reefs during breeding season may help preserve coral reefs.